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Outcomes of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (major route) and CYP2C9 (insignificant route). For that reason, inhibitors of those isoenzymes might minimize sildenafil clearance and inducers of those isoenzymes may maximize sildenafil clearance.Viagra isn’t permitted for use in women.* It’s not re